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PDF: Computational Systems Neurobiology

Download 4 times Source: www.symbionicproject.org // Topic: Biology File Size: 6043.37 kb // Total of Page: - Page(s) Last download by armmclub Last download on: 9 months ago Share this info: Short Desciption: Why computer simulations in Biology. ?. Complexity of biological systems. ?. Structural complexity: molecular and cellular levels ... Content Inside: Computational Systems Neurobiology Nicolas Le Novère, EMBL-EBI Why computer simulations in Biology · Complexity of biological systems Structural complexity: molecular and cellular levels Functional complexity: network of relations, non-boolean relations · Limitations of analytical approaches Intractable system of equations Existence of chaotic behaviours Experiments often provides snapshots of processes · Faster and cheaper computers Computing can complement experimental investigations by: · Storage, retrieval and analysis of data Making predictions about future experiments Experiment Design of new hypothesis/experiments Virtual experiments, not feasible in reality Analysis of results Model refinement Simulation in Neurobiology · Hodgkin and Huxley "A Quantitative Description of Membrane Current and its Application to Conduction and Excitation in Nerve". J Physiol 1952, 117: 500-544 · Rall "Branching dendritic trees and motoneuron membrane resistivity". Exp Neurol 1959, 1: 491-527 · [NEURON] Hines "A program for simulation of nerve equations with branching geometries". Int J Biomed Comput 1989, 24:55-68 · [GENESIS] Wilson, Bhalla, Uhley, Bower "GENESIS : A system for simulating neural networks." Advances in neural information processing systems. Touretzky, D. ed, 1989, pp. 485-492 · Land, Salpeter, Salpeter "Kinetic