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PDF: 2 Molecular biology of gene regulation

Download 172 times Source: www.diss.fu-berlin.de // Topic: Biology File Size: 544.99 kb // Total of Page: 18 Page(s) Last download by szczurek Last download on: 3 weeks ago Share this info: Sample of page (click to enlarge) Short Desciption: 2 Molecular biology of gene. regulation. Entering the post-genomic era where sequencing of whole genomes has become routine ... Content Inside: 2 Molecular biology of gene regulation Entering the post-genomic era where sequencing of whole genomes has become routine work, we have the opportunity to unravel a plethora of functional elements, which ultimately give rise to the complexity of life. We might one day understand the function and interactions of all constituents of a given genome by studying subsets of these constituents. This thesis is about computational approaches to mine for sequence elements that are vital components of gene regulation in higher organisms like mammals. Other issues that are addressed include building up a repository for the genome-wide annotation of regulatory elements and the exploration of associations between predicted patterns of regulatory elements and measured gene expression levels. We firstly give some biological background on the elements of a eukaryotic genome (Section 2.1). Then, we cover in greater detail the DNA and protein components of gene regulation in proximal promoter regions (Section 2.2).

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